Formulasi Tablet Ekstrak Daun Sirsak (Annona Muricata L.) dengan Variasi Kadar Primojel sebagai Bahan Penghancur

Abstract

The leaves of the soursop plant contains flavonoids, phytosterols, calcium oxalate, alkaloids, tannins, and some other chemical constituents including Annonaceous acetogenin. In addition to the content of acetogenin which act as antioxidants, soursop leaves also contain flavonoids. Falvonoid is a natural phenolic compound that has potential as an antioxidant, and have bioactivity as medicine. The purpose of this study are to know the effect of variations in the levels of use of materials crusher primojel on the physical properties of soursop leaf extract tablet (Annona muricata. L) and to get good primojel concentration as a tablet crusher for soursop leaf extract. Tablet soursop leaf extract is divided into three formulations with variations in levels of material as the material crusher primojel namely F1 4%, F2 6%, and F3 8%, using a wet granulation technique. Testing views of the physical properties of the tablet is organoleptis, uniformity of weight, hardness, friability, and a soluble tablet. The results of the research, Formulation 1 (primojel 4%) has a hardness of 5.76 ± 0.32 kg / cm2, 0.07 ± 0.08% friability, disintegration time of 7.73 ± 1.55 minutes. Formula 2 (primojel 6%) has a hardness of 6.51 ± 0.40 kg / cm2, 0.09 ± 0.06% friability, disintegration time of 8 ± 0.5 min. Formula 3 (primojel 8%) has a hardness of 5.19 ± 0.43 kg / cm2, 0.03 ± 0.01% friability, disintegration time 6.15 ± 1.44 minutes.