Cost effectiveness analysis of antihypertensive drugs usage by combination of ACEI–diuretic and ARB–diuretic in outpatient hypertension therapy at Leuwiliang regional general hospital Bogor 2015

Abstract

Hypertension is a cardiovascular disease that can lead to increased morbidity and mortality. The prevalence of hypertension in Indonesia is 7.6 (Riskesdas 2007) in 2013 increased to 9.5. Therapy of hypertensive takes a long time and expensive. This study to determine the effectiveness of drug combination and cost effectiveness of combination therapy of antihypertensive drugs ACEI-Diuretic and ARB-Diuretic in outpatient of hypertension at RSUD Leuwiliang Bogor 2015. This study was a cohort design to measure the effectiveness and Cost Effectiveness Analysis to measure the effeciency of cost of antihypertensive combination drugs ACEI-Diuretic and ARB-Diuretic. The data for this study were collected prospectively from medical record of outpatient hypertensive visit to Leuwiliang Regional General Hospital Bogor June-December 2015. The samples size were 70 patients with hypertension who meet the inclusion and exclusion criteria and were divided into 2 groups. Each group consisted of 35 hypertensive patients, each receiving combination antihypertensive drugs and observed for 3 months. Results showed that the antihypertensive combination drug of ACEIDiuretic controlled blood pressure 91.1% and unit cost IDR 837.670- Combined ARB-Diuretic controlled blood pressure 76.4% and unit cost IDR 1.133.520,-. This means that the combination drug ACEI-Diuretic is more effective and efficient than the ARB-Diuretic combination. The combination drug ACEI-Diuretic is more effective and efficient than the ARB-Diuretic combination, evidenced by the value of ACER 837.670 and the value of ICER -233.585.