Formulasi Tablet Ekstrak Daun Sirsak (Annona muricata L.) dengan Variasi Kadar Crospovidone Sebagai Bahan Penghancur

Abstract

The soursop leaf contain of several active compounds including flavonoid that are know efficatios as antioxidant. The use of soursop leaf as antioxidant merely boil with water by people. Necessary to develop new innovation become a tablet for increased comfort with its use more practical potential and more stable in storage when copared with pharmaceutical preparation in liquid or suspension. The purpose of this study was to determine the tablet disintegration time of soursop leaf extract (Annona muricata L.) with crospovidone disintegrant content variation and to determine the best level of the best destroyer in accordance with the result of evaluation of physical properties its tablets. Tablets made by wet granulation methode with ingredients crospovidone 2%, 3,5% and 5%. Granules produced in water content test, flow time test, angle of repost and tap dencity. Then resulting tablets are tested their physical properties. Result study; formula I has weight uniformity (CV) 1,05%, hardness 5,37±0,42 kg, friability 0,16±0,22% and disintegranion time test 14,19 minutes. Formula II has weight unformity (CV) 2,18%, hardness 5,31±0,3 kg, friability 0,36±0,3% and disintegration time test 0,1 minutes. Formula III has weight uniformity (CV) 1,98%, hardness 5,40±0,68 kg, friability 0,55±0,7% and disintegration time test 5,68±0,7 minutes. The result showed that variation in levels of crospovidone accelerate tablet disintegration time. Fromula optimum achived in formula III with of crospovidone is 5%. Key words : crospovidone, disintegrant, tablet, soursop (Annona muricata L.)