Prevalence of Estrogen Receptor Alpha (ESRa) Gene Polymorphism in Javenese postmenopausal Women with DM type 2 .

Abstract

Polymorph isms of estrogen receptor alpha (ESR-a) gene may cause deleterious effect to metabolic action, particularly in the glucose homeostasis due to insulin resistance. Polymorphisms in the ESR-a gene have been associated with the occurrence of breast cancer, menopausal osteoporosis, recurrent abortions, arterial hypertension, T2DM, dyslipidemia, cardiovascular complications such as coronary heart diseases and stroke. It is understood that in postmenopausal women the incidence of T2DM as well as its cardiovascular complications will increase.