Formulasi Dan Uji Aktivitas Anti Bakteri Nanoemulgel Deodoran Minyak Atsiri Daun Jeruk Purut (Citrus Histrix) Terhadap Bakteri Staphylococcus Epidermidis

Abstract

The use of deodorant is a solution that allows users to handle the subject of body odor by killing bacteria or inhibiting mechanism as an agent for anti-body odor. Previous research has been done to prove that the essential oil of kaffir lime leaves could inhibit the growth of E. coli and P. acnes. So it needs to study the formulation on the latest preparations such as nanoemulgel and test the antibacterial activity against bacteria that cause body odor (S. epidermidis). The purpose of this study was to see whether the essential oil of kaffir lime leaves (citrus hystrix) have antibacterial activity against S. Epidermidis bacteria and determinenanoemulgel deodorant antibacterial activity of essential oil of kaffir lime leaves (citrus hystrix) against bacteria S.epidermidis. Manufacture nanoemulgel using titration method with an active ingredient of essential oils distilled lime leaves. The concentration used is different in each formulation, among others F1 0.25; F2 0.5%; F3 1%. Then the physical properties test of the preparation includes organoleptic testing, homogeneity, viscosity, pH, and the particle size as well as to test the antibacterial activity. The results showed that the particle size obtained nanoemulgel dosage is 15,41±0,50 nm, with a pH close to 5,87±0,56 and good homogeneity with the distinctive aroma of essential oils. While on test antibacterial activity against S. epidermidis MIC obtained at a concentration of 0.5% essential oil with 1.2 cm wide inhibitory region and in all formulations showed the presence of antibacterial activity in S. epidermidis.